Know How the Top 20 Medications Interact in Your Body
We appreciate your interest in gaining a deeper understanding of the intricate interactions between medications and genetic biomarkers.
Peregrine WORx is committed to empowering individuals with knowledge that enables informed healthcare decisions. In response to your request, we present the Comprehensive Drug-Gene Interaction List derived from our analysis of the top 20 genes and medications associated with adverse drug reactions.
This is a compilation of medications that are recommended by the FDA and PharmGKB that are actionable and require further testing. Their guidance is reflected by the level of evidence, with level A the strongest and level D the weakest.
Table 1: FDA and PharmGKB Count of Actionable Medications List
Table 2: Count of medications in each CPIC level
Table 3: Genes matching up with the medications
We believe that this comprehensive drug-gene interaction list will serve as a valuable resource in navigating the complexities of pharmacogenomics. The list may change over time due to new research and updated guidelines. Should you have any further questions or require additional information, our team at Peregrine WORx is here to assist you.
To review a list from the FDA, which is available publicly, to stay up to date, visit https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling
CPIC regularly updates their list of drug-gene guidelines available at https://cpicpgx.org/
PharmGKB is the Dutch Pharmacogenomics Working Group, CPIC, Canadian, French, and other professional societies annotated database, guidelines, and education platform for everyone to visit at https://www.pharmgkb.org/guidelineAnnotations
Liu D, Olson KL, Manzi SF, Mandl KD. Patients dispensed medications with actionable pharmacogenomic biomarkers: rates and characteristics. Genet Med. 2021 Apr;23(4):782-786. doi: 10.1038/s41436-020-01044-2. Epub 2021 Jan 8. PMID: 33420348; PMCID: PMC9067543.
Cheers,
Blair Curless, PharmD, PhD
blair@peregrineworx.com
10719 Alpharetta Highway, #1388
Roswell, GA 30077
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404-500-0346:f
Peregrine WORx | Tamvoes | LinkedIn: www.linkedin.com/blaircurless